Antibodies Reactive with Native Lysozyme Elicited by a Completely Synthetic Antigen
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چکیده
منابع مشابه
Antiviral response elicited by a completely synthetic antigen with built-in adjuvanticity.
In a previous study we demonstrated that antiviral response against the coliphage MS-2 can be elicited by immunization with a synthetic antigen consisting of a conjugate (P2-A -- L) of a synthetic fragment (P2) of the virus coat protein attached to a synthetic polymeric carrier. The antiviral response was induced when the antigen was administered in complete Freund's adjuvant or when it was adm...
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A synthetic conjugate, prepared by covalent binding of a lysozyme fragment (sequence 64-83, denoted "loop" peptide) to a synthetic branched polypeptide, elicited in rabbits the formation of antibodies with specificity directed against a unique region in native lysozyme. These anti-"loop" antibodies were isolated immunospecifically on a lysozyme-cellulose immunoadsorbent. Antibodies with a simil...
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Three 17-residue peptides, presenting from 65% to 70% sequence homology, and one endecapeptide, with no apparent homology with the first three, were chemically synthesized and investigated in their ability to elicit rabbit antipeptide antibodies. The complex cross reactivities of the antisera were investigated by testing the binding of the antibodies to the intact peptides, to their enzymatic f...
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Objective(s): Detection of circulating Mycobacterium tuberculosis (M. tuberculosis) antigens is promising in Tuberculosis (TB) diagnosis. However, not a single antigen marker has been found to be widely expressed in all TB patients. This study is aimed to prepare broadly reactive polyclonal antibodies targeting multiple antigen markers (multi-target antibodies) and evaluate their efficacies in ...
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The possibility was studied of eliciting antibodies that are able to recognize Neisseria meningitidis outer membranes by immunizing with synthetic peptides containing the sequence of the exposed loop 1 (variable region 1 or VR1) subtype P1.19 from meningococcal PorA protein. It has been shown that the antibodies elicited by immunization with a cyclic synthetic peptide containing the apex amino ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1971
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.68.7.1450